You're really making me think. Now I can't go to sleep until I know myself.
Gotta dust off the old static mechanics text book!
It does not really make much difference. The most significant thing is the torque on the bearings. The torque or the moment are the forces on the tip of the cutter times the distance to a bearing.
To make things simple say you have an even 10 lb force on the bit and it's 10 inches from the bearing.
The moment is 10lbs * 10" = 100 lb-in
If you reduce that distance to 5" you get only (10 lbs * 5" = 50lb-in) half the moment on the bearing for the same 10 lb force on the bit.
Another way to look at it is like when you put a pipe on the end of a wrench to take out a stuck bolt. You get a whole lot more torque on a long wrench.
This was just a simple illustration. In real life things are a little more complicated with forces & moments on multiple planes & vectors not to mention the dynamics when its all in motion.
On multiple bearings the moment on the bit exerts forces on the two rails in opposite direction of each other.
Here, I'll just draw a diagram I'm not good with words.
A whole essay can be written about this alone.
Note that the diagrams to the right are the equivalent of your different layouts.
Hope this helps.
Anyone, if I'm wrong let me know!
But give me a break it's 3:00am & I can't sleep.
Chris